The Antioxidant from Ethanolic Extract of Rosa cymosa Fruits Activates Phosphatase and Tensin Homolog In Vitro and In Vivo: A New Insight on Its Antileukemic Effect

  title={The Antioxidant from Ethanolic Extract of Rosa cymosa Fruits Activates Phosphatase and Tensin Homolog In Vitro and In Vivo: A New Insight on Its Antileukemic Effect},
  author={Kuan‐Chi Wang and Yi-Chang Liu and Mohamed El‐Shazly and Shou-Ping Shih and Ying-Chi Du and Y M Hsu and Hung‐Yu Lin and Yu-Cheng Chen and Yang chang Wu and Shyh-Chyun Yang and Mei-Chin Lu},
  journal={International Journal of Molecular Sciences},
Rosa cymosa Tratt is a Chinese herbal remedy that is used in the treatment of diarrhea, burns, rheumatoid arthritis, and hemorrhage. Despite its use in Asian folk medicine, there are limited reports on the biological activity of R. cymosa fruits. This study focused on the investigation of the antitumor effect of the antioxidative ethanolic extract of R. cymosa fruits (RCE) along with its underlying mechanism of action. RCE showed a potent cytotoxic effect against Sup-T1 and Molt-4 lymphoblastic… 

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