The Antioxidant Vitamin E Modulates Amyloid β-Peptide-Induced Creatine Kinase Activity Inhibition and Increased Protein Oxidation: Implications for the Free Radical Hypothesis of Alzheimer's Disease

@article{Yatin1999TheAV,
  title={The Antioxidant Vitamin E Modulates Amyloid β-Peptide-Induced Creatine Kinase Activity Inhibition and Increased Protein Oxidation: Implications for the Free Radical Hypothesis of Alzheimer's Disease},
  author={Servet M. Yatin and Michael Aksenov and David Butterfield},
  journal={Neurochemical Research},
  year={1999},
  volume={24},
  pages={427-435}
}
Amyloid β-peptide (Aβ), the main constituent of senile plaques in Alzheimer's disease (AD) brain, is hypothesized to be a key factor in the neurodegeneration seen in AD. Recently it has been shown by us and others that the neurotoxicity of Aβ occurs in conjunction with free radical oxidative stress associated with the peptide. Aβ(1–40) and several other fragments of the Aβ sequence are associated with free radicals in solution that are detectable using electron paramagnetic resonance… CONTINUE READING

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