The Antioxidant Effect of Fermented Papaya Preparation in the Oral Cavity

@article{Fibach2015TheAE,
  title={The Antioxidant Effect of Fermented Papaya Preparation in the Oral Cavity},
  author={Eitan Fibach and Isaac Ginsburg},
  journal={Phytotherapy Research},
  year={2015},
  volume={29},
  pages={1317 - 1322}
}
Oxidative stress has been recognized to play important roles in various diseases, including of the oral cavity. However, nutritional supplementation of antioxidants to ameliorate the consequences of oxidative stress is debatable. One caveat is that oxidative status is often measured under non‐physiological conditions. Here, we investigated the antioxidant potential of fermented papaya preparation (FPP), a product of yeast fermentation of Carica papaya Linn, under conditions that prevail in the… 
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Discovering the Health Promoting Potential of Fermented Papaya Preparation—Its Future Perspectives for the Dietary Management of Oxidative Stress During Diabetes
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The focus of this review is to appraise the potential of oxidative stress reduction strategies of FPP and discuss its holistic approach in disease prevention and management, with a particular focus on diabetes and cancer.
The Relationship Between Salivary Redox, Diet, and Food Flavor Perception
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The effect of food on the antioxidant capacity of saliva and the impact of salivary antioxidant capacity on flavor perception are reviewed after a brief presentation of the different molecules involved.
Effects of the Aqueous Extract from Tabebuia roseoalba and Phenolic Acids on Hyperuricemia and Inflammation
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The results show that the AEL of Tabebuia roseoalba can be a promising agent for treatment for gout and inflammatory diseases and suggest that caffeic and chlorogenic acids may be responsible for the activities demonstrated by the species.
The Effect of Fermented Papaya Preparation on Radioactive Exposure
TLDR
It is suggested that FPP might serve as a radioprotector, and its effect on DNA damage and mutagenicity might reduce the long-term effects of radiation, such as primary and secondary malignancy.
Effects of Standardised Fermented Papaya Gel on Clinical Symptoms, Inflammatory Cytokines, and Nitric Oxide Metabolites in Patients with Chronic Periodontitis: An Open Randomised Clinical Study
TLDR
Although not acting directly as antibiotic, SFPG acted in synergy with human granulocytes blocking adaptive catalase induction in S. aureus in response to granulocyte-derived oxidative stress, thus enhancing intracellular bacterial killing.
Call for mobilization of functional foods, antioxidants, and herbal antivirals in support of international campaign to control coronavirus
TLDR
Clinical trials investigating antioxidant and/or pre- pro-biotic supplements in patients with COVID-19 infections and the measurement of appropriate variables such as ROS, RNS, IgA, SOD, lysozyme production, RIBs, and food intake are suggested to yield preliminary data for future trials.
Neuroprotective effect of fermented papaya preparation by activation of Nrf2 pathway in astrocytes
TLDR
It is indicated that FPP enhances the anti-oxidative capacity through activation of Nrf2 in astrocytes, suggesting it may provide neuroprotection in oxidative stress-related neurodegenerative diseases.
Polyphenols in Dental Applications
TLDR
The present review is aimed to show that molecules from all the major classes of polyphenolics allow for low coast improvements of dental materials and engineering of dental tissues.
Beneficial effects of a Fermented Papaya Preparation for the treatment of electrohypersensitivity self-reporting patients: results of a phase I-II clinical trial with special reference to cerebral pulsation measurement and oxidative stress analysis
TLDR
Whether FPP treatment is well tolerated, can improve clinical outcomes, and normalize biological abnormalities is tested to suggest a beneficial clinical and biological therapeutic effect of FPP in EHS self-reporting patients.

References

SHOWING 1-10 OF 33 REFERENCES
The antioxidant effect of fermented papaya preparation involves iron chelation.
  • E. Prus, E. Fibach
  • Biology
    Journal of biological regulators and homeostatic agents
  • 2012
TLDR
The results indicate that FPP reduces LIP and ROS, and suggests that its antioxidant mechanism is related, at least in part, to iron chelation, which is related to oxidative stress-mediated toxicity.
Applications and bioefficacy of the functional food supplement fermented papaya preparation.
Protective effect of fermented papaya preparation on stress-induced acute gastric mucosal lesion
TLDR
The results suggest that oral administration of FPP provides protection against WIRS-induced acute gastric mucosal lesions through its anti-oxidative and anti-inflammatory properties.
The Oxidant-Scavenging Abilities in the Oral Cavity May Be Regulated by a Collaboration among Antioxidants in Saliva, Microorganisms, Blood Cells and Polyphenols: A Chemiluminescence-Based Study
TLDR
It is shown that saliva can strongly decompose both oxygen and nitrogen species, and that saliva and its antioxidants are considered regulators of the redox status in the oral cavity under physiological and pathological conditions.
Salivary antioxidants and periodontal disease status
TLDR
An improved understanding of the role antioxidants play in periodontitis, and the influence of nutrition on antioxidant status, may lead to a possible nutritional strategy for the treatment of periodontal disease.
Fermented papaya preparation as redox regulator in blood cells of β‐thalassemic mice and patients
TLDR
The results suggest that FPP, as a potent antioxidant, might alleviate symptoms associated with oxidative stress in severe forms of thalassemia.
Ferric nitrilotriacetate induced DNA and protein damage: inhibitory effect of a fermented papaya preparation.
TLDR
EPR spin trapping studies demonstrated that antioxidant properties of FPP are related to both hydroxyl scavenging as well as iron chelating properties and protected supercoiled plasmid DNA against Fe-NTA plus H2O2 induced single and double strand breaks.
Polyphenols enhance total oxidant-scavenging capacities of human blood by binding to red blood cells
TLDR
It is suggested that circulating erythrocytes and possibly also other blood cells might be constantly coated by polyphenols from supplemented nutrients, which act as antioxidant depots and can thus act as protectors against the harmful consequences of oxidative stress.
Characterization of the antioxidant profile of human saliva in peri-implant health and disease.
TLDR
Total antioxidant status (TAS) of saliva and concentration of uric acid and ascorbate, which are the main salivary antioxidants, are significantly decreased in patients with peri-implant disease.
Is there a potential application of a fermented nutraceutical in acute respiratory illnesses? An in-vivo placebo-controlled, cross-over clinical study in different age groups of healthy subjects.
TLDR
FPP supplementation during 1 month resulted in higher salivary IgA and increase in phase II and SOD enzyme expression, i.e the most important antioxidant in the respiratory tract, and the biological significance of these effects remains to be demonstrated in longer clinical trials.
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