The Antihæmorrhagic Vitamin of the Chick.: Occurrence And Chemical Nature

  title={The Antih{\ae}morrhagic Vitamin of the Chick.: Occurrence And Chemical Nature},
  author={Henrik Dam},
  • H. Dam
  • Published 1 April 1935
  • Biology
  • Nature
IN earlier papers1,2 a new deficiency disease in chicks has been described which is characterised by a tendency to large hæmorrhages. It has been ascribed to the lack of a specific antihæmorrhagic factor which is different from vitamin C. More recent work has demonstrated that the factor in question is a fat-soluble vitamin occurring in hog liver fat, in hemp seed and certain vegetables, such as tomatoes and kale, and—to a less degree—in many cereals. Beef muscle, calf brain and beef lungs… 
Dietary Hæmorrhagic Disease in Chicks
A NUTRITIONAL disease of chicks characterised by subcutaneous, intramuscular and abdominal hæmorrhages, prolonged blood-clotting time and erosions of the gizzard lining has been described in detail
A Nutritional Deficiency causing Gizzard Erosions in Chicks
Gizzard erosion is investigated with the object of determining whether it is a true portion of the hæmorrhagic syndrome or a separate disease not caused by deficiency of the antihæmor Rhagic vitamin.
The Anti-hemorrhagic Vitamin
Preliminary indications of the existence of a dietary disease in which chickens suffer from hemorrhagic tendencies and delayed blood clotting may be seen in a number of papers describing results obtained in experiments dealing with various phases of poultry nutrition.
The development of vitamin K and its clinical uses in the neonatal period
It was not until seven years later that Schonheyder (1936), also of the University of Copenhagen staff, demonstrated a deficiency of prothrombin in the plasma of chicks on a vitamin K-free diet, and the addition of vitamin K to their diet was followed not only by a rapid cure of their haemorrhagic tendency but also by a coincident rise of their plasma prothrome to a normal value.
The Alleged Intoxication Factor in Fish Meal
Abstract IT HAS been stated by Cook and Scott (1935a, b) that a condition, the main symptoms of which were (1) severe anemia, (2) increased clotting time of blood, (3) distortion of the blood picture
Work in the author’s laboratory has the potential of generating knowledge of importance to medical sciences by providing information about diluents useful for cold-storage of cells, about enzymes whose activities may be applicable to studies of human tissues, and about mitochondria.
Vitamin K metabolism.
Improvements in the assay method based on the restoration of normal clotting time in hemorrhagic chicks led to the proposal that a lack of vitamin K caused a deficiency in prothrombin activity and that vitamin K might be some kind of coenzyme or prosthetic group required for active prothROMbin (Schoenheyder, 1936).
The expanse of unexplored fields in the domain of nutrition is well illustrated by the discovery of Trager and co-workers that a factor essential for growth of mosquito larvae is present in normal human urine but deficient in that of pernicious anemia patients.
The Relationship of Vitamin K to Mortality from Cecal Coccidiosis
Experiments were designed to study the possibility of reducing mortality from cecal coccidiosis by the addition of MSB to a vitamin K low diet.


Hæmorrhages in Chicks Reared on Artificial Diets: a New Deficiency Disease
It was observed that the animals often exhibited, extensive internal haemorrhages when they were fed a ration consisting of vitamin A-free casein 20, Marmite 10, salt mixture 4·5, starch 65·5 and varying amounts of cod liver oil concentrates.
A deficiency disease in chicks resembling scurvy.