The Antiangiogenic Activity of rPAI-123 Inhibits Vasa Vasorum and Growth of Atherosclerotic Plaque

@article{Drinane2009TheAA,
  title={The Antiangiogenic Activity of rPAI-123 Inhibits Vasa Vasorum and Growth of Atherosclerotic Plaque},
  author={Mary C. Drinane and Jessica Mollmark and Lyubomir Zagorchev and Karen L. Moodie and Baiming Sun and Amy Hall and Samantha L. Shipman and Peter M. Morganelli and Michael Simons and Mary Jo Mulligan-Kehoe},
  journal={Circulation Research},
  year={2009},
  volume={104},
  pages={337-345}
}
  • Mary C. Drinane, Jessica Mollmark, +7 authors Mary Jo Mulligan-Kehoe
  • Published 2009
  • Biology, Medicine
  • Circulation Research
  • Plaque vascularity has been implicated in its growth and stability. However, there is a paucity of information regarding the origin of plaque vasculature and the role of vasa vasorum in plaque growth. To inhibit growth of vasa vasorum in atherogenic mice and assess its effect on plaque growth, we used a truncated plasminogen activator inhibitor (PAI)-1 protein, rPAI-123, that has significant antiangiogenic activity. Female LDLR−/−ApoB-48–deficient mice fed Paigen’s diet without cholate for 20… CONTINUE READING

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