The Antiallergic Mast Cell Stabilizers Lodoxamide and Bufrolin as the First High and Equipotent Agonists of Human and Rat GPR35

@article{Mackenzie2014TheAM,
  title={The Antiallergic Mast Cell Stabilizers Lodoxamide and Bufrolin as the First High and Equipotent Agonists of Human and Rat GPR35},
  author={A. Mackenzie and G. Caltabiano and T. Kent and Laura Jenkins and Jennifer E. McCallum and B. Hudson and S. Nicklin and L. Fawcett and Rachel Markwick and S. Charlton and G. Milligan},
  journal={Molecular Pharmacology},
  year={2014},
  volume={85},
  pages={104 - 91}
}
Lack of high potency agonists has restricted analysis of the G protein–coupled receptor GPR35. Moreover, marked variation in potency and/or affinity of current ligands between human and rodent orthologs of GPR35 has limited their productive use in rodent models of physiology. Based on the reported modest potency of the antiasthma and antiallergic ligands cromolyn disodium and nedocromil sodium, we identified the related compounds lodoxamide and bufrolin as high potency agonists of human GPR35… Expand
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