The Anti-inflammatory Protein TSG-6 Regulates Chemokine Function by Inhibiting Chemokine/Glycosaminoglycan Interactions*

@inproceedings{Dyer2016TheAP,
  title={The Anti-inflammatory Protein TSG-6 Regulates Chemokine Function by Inhibiting Chemokine/Glycosaminoglycan Interactions*},
  author={Douglas P Dyer and Catherina L. Salanga and Scott C. Johns and Elena Valdambrini and Mark M. Fuster and Caroline M. Milner and Anthony J Day and Tracy M. Handel},
  booktitle={The Journal of biological chemistry},
  year={2016}
}
TNF-stimulated gene-6 (TSG-6) is a multifunctional protein secreted in response to pro-inflammatory stimuli by a wide range of cells, including neutrophils, monocytes, and endothelial cells. It has been shown to mediate anti-inflammatory and protective effects when administered in disease models, in part, by reducing neutrophil infiltration. Human TSG-6 inhibits neutrophil migration by binding CXCL8 through its Link module (Link_TSG6) and interfering with the presentation of CXCL8 on cell… CONTINUE READING

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