The Anti-aging Protein Klotho Enhances Oligodendrocyte Maturation and Myelination of the Central Nervous System

We have previously shown that myelin abnormalities and loss characterize the normal aging process of the brain and that an age-associated reduction in Klotho is conserved across species. Predominantly generated in brain and kidney, Klotho overexpression extends life span, whereas loss of Klotho accelerates the development of aging-like phenotypes. While the… CONTINUE READING