The Anti-Inflammatory and Anti-Oxidant Mechanisms of the Keap1/Nrf2/ARE Signaling Pathway in Chronic Diseases

@article{Tu2019TheAA,
  title={The Anti-Inflammatory and Anti-Oxidant Mechanisms of the Keap1/Nrf2/ARE Signaling Pathway in Chronic Diseases},
  author={Wenjun Tu and Hong Wang and Song Li and Q. Liu and H. Sha},
  journal={Aging and Disease},
  year={2019},
  volume={10},
  pages={637 - 651}
}
Oxidative stress is defined as an imbalance between production of free radicals and reactive metabolites or [reactive oxygen species (ROS)] and their elimination by through protective mechanisms, including (antioxidants). This Such imbalance leads to damage of cells and important biomolecules and cells, with hence posing a potential adverse impact on the whole organism. At the center of the day-to-day biological response to oxidative stress is the Kelch-like ECH-associated protein 1 (Keap1… Expand
Roles of Nrf2 in Liver Diseases: Molecular, Pharmacological, and Epigenetic Aspects
TLDR
Detailed and updated evidence regarding Nrf2 and its involvement in the development of the main liver diseases such as alcoholic liver damage, viral hepatitis, steatosis, steatohepatitis, cholestatic damage, and liver cancer is provided. Expand
NRF2 and the Ambiguous Consequences of Its Activation during Initiation and the Subsequent Stages of Tumourigenesis
TLDR
Cancer chemoprevention and the discovery of the essential role played by NRF2 in orchestrating protection against chemical carcinogenesis are described and described. Expand
Identification and evaluation of a napyradiomycin as a potent Nrf2 activator: Anti-oxidative and anti-inflammatory activities.
TLDR
Compound 1 was confirmed to induce both mRNA and protein levels of Nrf2-dependent antioxidant enzyme genes in BV-2 microglial cells and suppress inflammatory mediators and intracellular reactive oxygen species and make it a promising therapeutic natural compound for various diseases associated with oxidative stress and inflammation. Expand
The multifaceted role of NRF2 in cancer progression and cancer stem cells maintenance.
TLDR
The dark side of NRF2 signaling in cancers discovered so far is described, showing that low ROS levels and refractory drug response of CSCs are mediated by the activation of NRf2 signaling. Expand
Regulation of redox processes in biological systems with the participation of the Keap1/Nrf2/ARE signaling pathway, biogenic selenium nanoparticles as Nrf2 activators
The article is devoted to the mechanisms of regulation of redox processes in cells, a review of the Keap1 / Nrf2 / ARE redox-sensitive signaling system as a fundamental pathway that plays a key roleExpand
Sestrin 2, a potential star of antioxidant stress in cardiovascular diseases.
TLDR
It is speculated that Sesn2 plays an important role in CVDs by stimulating the process of antioxidation and promoting the adaptation of cells to stress conditions and/or the environment, opening a new avenue for related therapeutic strategies. Expand
Preventive Role of Cannabinoids Derivate against Methylphenidate-Induced Oxidative Stress and Inflammation: The Hypothetical Function of Keap1/Nrf2/ARE Signaling and Proposal of a Treatment Strategy for Neurodegeneration
TLDR
Neuroprotective approach to the prevention, treatment, or management of methylphenidate‐induced oxidative stress, inflammation, and mitochondrial dysfunction through a novel neuroprotective agent is continuously superior to any other therapeutic strategy. Expand
Role of Nrf2 in cell senescence regulation
TLDR
This review focuses on the recent advances and progress made in elucidating the regulatory mechanism of Nrf2 in the cell senescence process, which involves coordinated regulation of multiple signaling molecules. Expand
Role of Nrf2 in Synaptic Plasticity and Memory in Alzheimer’s Disease
Nuclear factor erythroid 2-related factor 2 (Nrf2) is an important transcription factor that reduces oxidative stress. When reactive oxygen species (ROS) or reactive nitrogen species (RNS) areExpand
The activation of nuclear factor-E2-related factor 2 (Nrf2)/heme oxygenase-1 (HO-1) signaling blunts cholestasis-induced liver and kidney injury.
Cholestasis is a severe clinical complication that severely damages the liver. Kidneys are also the most affected extrahepatic organs in cholestasis. The pivotal role of oxidative stress has beenExpand
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 187 REFERENCES
Toxico-pharmacological perspective of the Nrf2-Keap1 defense system against oxidative stress in kidney diseases.
  • H. Saito
  • Chemistry, Medicine
  • Biochemical pharmacology
  • 2013
TLDR
Therapeutic approaches to prevent oxidative stress via activation of the Nrf2-Keap1 signaling and/or suppression of uremic toxin-induced ROS production could be effective strategies for maintaining kidney function. Expand
Dietary Regulation of Keap1/Nrf2/ARE Pathway: Focus on Plant-Derived Compounds and Trace Minerals
TLDR
Priming the Keap1/Nrf2/ARE pathway by upregulating these enzymes prior to oxidative stress or xenobiotic encounter increases cellular fitness to respond more robustly to oxidative assaults without activating more intense inflammatory NFκB-mediated responses. Expand
The Keap1–Nrf2 pathway: promising therapeutic target to counteract ROS-mediated damage in cancers and neurodegenerative diseases
TLDR
It is suggested that the Keap1–Nrf2 system is a potential therapeutic target to combat cancer and NDD by designing and developing modulators (inhibitors/activators) for Nrf2 activation. Expand
A protective role of nuclear factor-erythroid 2-related factor-2 (Nrf2) in inflammatory disorders.
TLDR
This review highlights the protective role of Nrf2 in inflammation-mediated disorders with special focus on the inflammatory signaling modulated by this redox-regulated transcription factor. Expand
Molecular and Chemical Regulation of the Keap1-Nrf2 Signaling Pathway
TLDR
How Nrf2 prevents tumor promotion, hampers the sensitivity of selected tumors against chemotherapy or radiotherapy, and reprograms the metabolism to facilitate the tumor proliferation is discussed. Expand
Chemopreventive role of anthocyanins in atherosclerosis via activation of Nrf2-ARE as an indicator and modulator of redox.
TLDR
This review highlights the gene expression induced by dietary anthocyanin via Nrf2 signaling on redox-regulated transcription factor in atherosclerosis disorders. Expand
Cell survival responses to environmental stresses via the Keap1-Nrf2-ARE pathway.
TLDR
The development of Nrf2 knockout mice has provided key insights into the toxicological importance of this pathway, and this review highlights the key elements in this adaptive response to protection against acute and chronic cell injury provoked by environmental stresses. Expand
The Keap1-Nrf2 system and diabetes mellitus.
TLDR
How the Keap1-Nrf2 system protects the body against diabetes mellitus and how perturbations in this system provoke the disease condition are now under intense investigation. Expand
Oxidative stress, inflammation, and cancer: how are they linked?
TLDR
Observations to date suggest that oxidative stress, chronic inflammation, and cancer are closely linked. Expand
Targeting the Transcription Factor Nrf2 to Ameliorate Oxidative Stress and Inflammation in Chronic Kidney Disease
TLDR
Given the role of impaired Nrf2 activity in CKD-induced oxidative stress and inflammation, interventions aimed at restoring Nrf1 may be effective in retarding CKD progression and the potential utility of targeting NRF2 in the treatment of CKD is provided. Expand
...
1
2
3
4
5
...