The Ankyrin Repeats of TRPV1 Bind Multiple Ligands and Modulate Channel Sensitivity

@article{Lishko2007TheAR,
  title={The Ankyrin Repeats of TRPV1 Bind Multiple Ligands and Modulate Channel Sensitivity},
  author={Polina V Lishko and Erik Procko and Xiangshu Jin and Christopher B. Phelps and Rachelle Gaudet},
  journal={Neuron},
  year={2007},
  volume={54},
  pages={905-918}
}
TRPV1 plays a key role in nociception, as it is activated by heat, low pH, and ligands such as capsaicin, leading to a burning pain sensation. We describe the structure of the cytosolic ankyrin repeat domain (ARD) of TRPV1 and identify a multiligand-binding site important in regulating channel sensitivity within the TRPV1-ARD. The structure reveals a binding site that accommodates triphosphate nucleotides such as ATP, and biochemical studies demonstrate that calmodulin binds the same site… CONTINUE READING
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