The Angiotensin IV System: Functional Implications

  title={The Angiotensin IV System: Functional Implications},
  author={John W. Wright and Luke T. Krebs and Jeffrey W. Stobb and Joseph W. Harding},
  journal={Frontiers in Neuroendocrinology},
The brain renin-angiotensin system has been implicated in the central regulation of the cardiovascular system, body water balance, and cyclic regulation of reproductive hormones and behaviors. It also exerts some influence over the secretion of pituitary hormones. This system appears to be complete with the necessary precursors and enzymes for the formation and degradation of biologically active forms of angiotensins and several binding subtypes that are presumed to mediate these and other… Expand
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The regulation of the inflammatory response through nuclear factor-kappab pathway by angiotensin IV extends the role of the renin angiotensin system in cardiovascular diseases.
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