The Androgen Receptor Antagonizes Wnt/β-Catenin Signaling in Epidermal Stem Cells

  title={The Androgen Receptor Antagonizes Wnt/β-Catenin Signaling in Epidermal Stem Cells},
  author={Kai Kretzschmar and D L Cottle and Pawel J. Schweiger and Fiona M Watt},
  booktitle={The Journal of investigative dermatology},
Activation of Wnt/β-catenin signaling in adult mouse epidermis leads to expansion of the stem cell compartment and redirects keratinocytes in the interfollicular epidermis and sebaceous glands (SGs) to differentiate along the hair follicle (HF) lineages. Here we demonstrate that during epidermal development and homeostasis there is reciprocal activation of the androgen receptor (AR) and β-catenin in cells of the HF bulb. AR activation reduced β-catenin-dependent transcription, blocked β-catenin… CONTINUE READING
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