The Analgesic Effect of Rolipram, a Phosphodiesterase 4 Inhibitor, on Chemotherapy-Induced Neuropathic Pain in Rats

@article{Kim2015TheAE,
  title={The Analgesic Effect of Rolipram, a Phosphodiesterase 4 Inhibitor, on Chemotherapy-Induced Neuropathic Pain in Rats},
  author={H. K. Kim and J. Y. Kwon and C. Yoo and S. Abdi},
  journal={Anesthesia & Analgesia},
  year={2015},
  volume={121},
  pages={822–828}
}
  • H. K. Kim, J. Y. Kwon, +1 author S. Abdi
  • Published 2015
  • Medicine
  • Anesthesia & Analgesia
  • BACKGROUND:Chemotherapy-induced neuropathic pain is a significant side effect of chemotherapeutic agents. Currently, there are no effective analgesics for chemotherapy-induced neuropathic pain. Rolipram is a selective phosphodiesterase 4 inhibitor, which increases intracellular cyclic AMP in nerve and immune cells. The aim of our study was to determine the analgesic effects of rolipram on paclitaxel (PAC)-induced neuropathic pain in rats. METHODS:Chemotherapy-induced neuropathic pain was… CONTINUE READING
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