The Analgesic Drug, Tramadol, Acts as an Agonist of the Transient Receptor Potential Vanilloid-1

  title={The Analgesic Drug, Tramadol, Acts as an Agonist of the Transient Receptor Potential Vanilloid-1},
  author={Rita Marincs{\'a}k and Bal{\'a}zs Istv{\'a}n T{\'o}th and Gabriella Czifra and Tam{\'a}s Szab{\'o} and L{\'a}szl{\'o} Kov{\'a}cs and Tam{\'a}s B{\'i}r{\'o}},
  journal={Anesthesia \& Analgesia},
BACKGROUND:Tramadol is an effective analgesic substance widely used in medical practice. Its therapeutic action have been mainly attributed to the activation of &mgr;-opioid receptors as well as to the inhibition of neurotransmitter reuptake mechanisms and various voltage- and ligand-gated ion channels of the nociceptive system. As transient receptor potential vanilloid-1 (TRPV1, “the capsaicin receptor”) has been shown to function as a central integrator molecule of pain sensation, our aim in… 

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