The Anabolic Androgenic Steroid Oxandrolone in the Treatment of Wasting and Catabolic Disorders

  title={The Anabolic Androgenic Steroid Oxandrolone in the Treatment of Wasting and Catabolic Disorders},
  author={Rhonda Orr and Maria A. Fiatarone Singh},
There has been increasing interest in the development of effective agents that can be safely used to promote anabolism in the clinical setting for patients with chronic wasting conditions as well as in the prevention and treatment of frailty associated with loss of muscle tissue in aging (sarcopenia).One such agent is the anabolic androgenic steroid (AAS) oxandrolone, which has been used in such clinical situations as HIV-related muscle wasting, severe burn injury, trauma following major… 


It has been demonstrated that improvements in body composition, muscle strength, and function are evident with oxandrolone treatment in a variety of chronic wasting conditions.

Sudden Cardiac Death in Anabolic-Androgenic Steroid Users: A Literature Review

This review aimed to focus on deaths related to AAS abuse to investigate the cardiac pathophysiological mechanism that underlies this type of death, which still needs to be fully investigated.

A Reappraisal of Oxandrolone in Burn Management

Future clinical trials are needed using larger sample sizes and long-term follow-up to determine whether oxandrolone in the context of rehabilitation programs can reduce mortality, lower treatment costs, and improve function outcomes among burn patients.

Oxandrolone in the treatment of burn injuries: A systematic review and meta-analysis.

There is evidence to suggest that Oxandrolone is a beneficial adjunct to the acute care of burn patients; shortening hospital stays and improving several growth and wound healing parameters, although monitoring liver enzymes is recommended.

Effects of Oxandrolone on Cardiometabolic Health in Boys With Klinefelter Syndrome: A Randomized Controlled Trial

Ox has positive effects on measures of cardiometabolic health in prepubertal boys with KS; however, it does lower HDL cholesterol and advance bone age.

Anabolic-Androgenic Steroids

The level of evidence for treating anabolic-androgenic steroid dependence is currently based on case reports and series as well as expert opinion, and knowledge of the psychiatric, physical, and laboratory findings aids detection.

Incidence of oxandrolone induced hepatic transaminitis in patients with burn injury.

Oxandrolone Treatment Results in an Increased Risk of Gonadarche in Prepubertal Boys With Klinefelter Syndrome

Two years of Ox treatment in prepubertal boys with KS results in an increased risk of early gonadarche, on average 2 years earlier than in Pl-treated boys, and Serum concentrations of testicular hormones and gonadotropins were not different between groups.

Downregulation of Androgen Receptors upon Anabolic-Androgenic Steroids: A Cause or a Flawed Hypothesis of the Muscle-Building Plateau?

There is no scientific basis for claiming that myocyte AR downregulation is the cause of the AAS-induced plateau in muscle gains, and seminal and recent evidence support that AASs upregulate ARs, eliciting greater anabolic effects on skeletal muscle receptors through a dose-dependent relationship.



Oxandrolone in ALS: Preliminary analysis

  • J. RosenfeldR. KingJ. Smith
  • Biology, Medicine
    Amyotrophic lateral sclerosis and other motor neuron disorders : official publication of the World Federation of Neurology, Research Group on Motor Neuron Diseases
  • 2000
Recent studies reveal that short-term administration of oxandrolone increases net protein synthesis in the muscle of healthy subjects, suggesting a possible mechanism for the enhanced protein synthesis.

Anabolic Effects of Oxandrolone After Severe Burn

In burn victims, oxandrolone improves muscle protein metabolism through enhanced protein synthesis efficiency, suggesting the efficacy of ox androlone in impeding muscle protein catabolism in cachectic, critically injured children.

Recent Developments in the Toxicology of Anabolic Steroids

The anabolic steroids are toxic drugs with both long and short term effects, and their abuse by athletes is to be decried, particularly in view of the frequent and prolonged use by the young.

Clinical review 138: Anabolic-androgenic steroid therapy in the treatment of chronic diseases.

It is recommended that AAS can be used for the treatment of patients with acquired immunodeficiency syndrome wasting and in severely catabolic patients with severe burns, and preliminary data in renal failure-associated wasting are also positive.

Evaluation of the effects of oxandrolone on malnourished HIV-positive pediatric patients.

Treatment with oxandrolone for 3 months in HIV-infected children was well-tolerated, safe, and associated with markers of anabolism.

Comparison of the anabolic effects and complications of human growth hormone and the testosterone analog, oxandrolone, after severe burn injury.

  • R. Demling
  • Medicine, Biology
    Burns : journal of the International Society for Burn Injuries
  • 1999

Oxandrolone in AIDS‐wasting myopathy

Oxandrolone, at a dose of either 5 mg/ day or 15 mg/day, in contrast to placebo, had a positive impact on the weight and well‐being of HIV‐seropositive patients suffering from wasting and weakness.

Anabolic steroid-induced hepatotoxicity: is it overstated?

Prior reports of anabolic steroid-induced hepatotoxicity based on elevated aminotransferase levels may have been overstated, because no exercising subjects, including steroid users, demonstrated hepatic dysfunction based on GGT levels.

Oxandrolone, an anabolic steroid, significantly increases the rate of weight gain in the recovery phase after major burns.

It is concluded that an anabolic steroid combined with increased protein intake can significantly increase the rate of restoration of weight gain postburn.

Use of anabolic agents in treatment of short children.