The Amyloid Hypothesis of Alzheimer's Disease: Progress and Problems on the Road to Therapeutics

@article{Hardy2002TheAH,
  title={The Amyloid Hypothesis of Alzheimer's Disease: Progress and Problems on the Road to Therapeutics},
  author={John Hardy and Dennis J. Selkoe},
  journal={Science},
  year={2002},
  volume={297},
  pages={353 - 356}
}
It has been more than 10 years since it was first proposed that the neurodegeneration in Alzheimer's disease (AD) may be caused by deposition of amyloid β-peptide (Aβ) in plaques in brain tissue. According to the amyloid hypothesis, accumulation of Aβ in the brain is the primary influence driving AD pathogenesis. The rest of the disease process, including formation of neurofibrillary tangles containing tau protein, is proposed to result from an imbalance between Aβ production and Aβ clearance. 

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Recent findings indicate that the main factor underlying the development and progression of AD is tau, not Aβ, and the deficiencies of the amyloid hypothesis are described.

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  • Biology
    Journal of neurochemistry
  • 2009
It is suggested that a major scientific need is to understand the normal function of amyloid‐β precursor protein (APP) and think how this may relate to the cell death in the disease process.

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This review will outline some of the key determinants that modulate Aβ’s activity and the cellular pathways and mechanisms involved.

Amyloid-beta, tau, and dementia.

  • A. Takashima
  • Biology, Psychology
    Journal of Alzheimer's disease : JAD
  • 2009
This article proposes a hypothesis that brain aging, characterized by neurofibrillary tangles in entorhinal cortex, is pre-requisite for development of AD.
...

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s ci en ce m ag .o rg D ow nl oa de d fr om 1 www.sciencemag.org SCIENCE Erratum post date 27 SEPTEMBER 2002 post date

  • by J. Hardy and D. J. Selkoe
  • 2002