The Amyloid Hypothesis of Alzheimer's Disease: Progress and Problems on the Road to Therapeutics

@article{Hardy2002TheAH,
  title={The Amyloid Hypothesis of Alzheimer's Disease: Progress and Problems on the Road to Therapeutics},
  author={John Hardy and Dennis J. Selkoe},
  journal={Science},
  year={2002},
  volume={297},
  pages={353 - 356}
}
It has been more than 10 years since it was first proposed that the neurodegeneration in Alzheimer's disease (AD) may be caused by deposition of amyloid β-peptide (Aβ) in plaques in brain tissue. According to the amyloid hypothesis, accumulation of Aβ in the brain is the primary influence driving AD pathogenesis. The rest of the disease process, including formation of neurofibrillary tangles containing tau protein, is proposed to result from an imbalance between Aβ production and Aβ clearance. 
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Amyloid-beta, tau, and dementia.
  • A. Takashima
  • Psychology, Medicine
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This article proposes a hypothesis that brain aging, characterized by neurofibrillary tangles in entorhinal cortex, is pre-requisite for development of AD.
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The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics The review should have been accompanied by the following conflict of interest declaration Dr
  • The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics The review should have been accompanied by the following conflict of interest declaration Dr
  • 2002
s ci en ce m ag .o rg D ow nl oa de d fr om 1 www.sciencemag.org SCIENCE Erratum post date 27 SEPTEMBER 2002 post date
  • by J. Hardy and D. J. Selkoe
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