The Amygdala, Social Behavior, and Danger Detection

@article{Amaral2003TheAS,
  title={The Amygdala, Social Behavior, and Danger Detection},
  author={David G. Amaral},
  journal={Annals of the New York Academy of Sciences},
  year={2003},
  volume={1000}
}
  • D. Amaral
  • Published 1 December 2003
  • Psychology, Biology
  • Annals of the New York Academy of Sciences
Abstract: The amygdala is a distinctive portion of the anterior temporal lobe that has been implicated in a variety of functions including expression of fear, modulation of memory, and mediation of social communication. While work on the rodent amygdala often deals with emotion, much of the research in nonhuman primates and in man deals with its role in the perception of social signals, such as facial expressions, and the maintenance of social position, such as in primate dominance hierarchies… 

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References

SHOWING 1-10 OF 34 REFERENCES

The human amygdala in social judgment

This investigation into the hypothesis that the human amygdala is required for accurate social judgments of other individuals on the basis of their facial appearance finds three subjects with complete bilateral amygdala damage to judge faces of unfamiliar people with respect to two attributes important in real-life social encounters: approachability and trustworthiness.

Fear and the human amygdala

The results show that bilateral, but not unilateral, damage to the human amygdala impairs the processing of fearful facial expressions, and it is proposed that the amygdala is required to link visual representations of facial expressions with representations that constitute the concept of fear.

The Primate Amygdala Mediates Acute Fear But Not the Behavioral and Physiological Components of Anxious Temperament

It is demonstrated that the primate amygdala is involved in mediating some acute unconditioned fear responses but the notion that the amygdala is the key structure underlying the dispositional behavioral and physiological characteristics of anxious temperament is challenged.

The effects of bilateral lesions of the amygdala on dyadic social interactions in rhesus monkeys (Macaca mulatta).

The results indicate that amygdala lesions in adult monkeys lead to a decrease in the species-normal reluctance to immediately engage a novel conspecific in social behavior, contrary to the idea that amygdalectomy produces a decreases in social interaction and increased aggression from conspecials.

The amygdala: vigilance and emotion

A review of available studies examining the human amygdala covers both lesion and electrical stimulation studies as well as the most recent functional neuroimaging studies, and attempts to integrate basic information on normal amygdala function with the current understanding of psychiatric disorders, including pathological anxiety.

Syndrome produced by lesions of the amygdala in monkeys (Macaca mulatta).

The extreme emotional changes seen after total amygdalectomy were found only in the monkey with the largest subtotal lesion, which suggests that both the hypoemotionality and the successive reversal deficit arise from the same underlying dysfunction.

Early stress and adult emotional reactivity in rhesus monkeys.

  • S. Suomi
  • Psychology, Biology
    Ciba Foundation symposium
  • 1991
This chapter examines the relationship between early social experiences and behavioural and emotional reactivity in adolescence and adulthood that has been established through extensive research with rhesus monkeys, and some general principles that have emerged will be outlined.

Consolidation of Visual Associative Long-Term Memory in the Temporal Cortex of Primates

The hypothesis that limbic neurons undergo rapid modification of synaptic connectivity and provide backward signals that guide the reorganization of neocortical neural circuits is proposed and the consolidation process can now be examined in primates using neurophysiolocical and molecular biological approaches.