The Amotl2 gene inhibits Wnt/β-catenin signaling and regulates embryonic development in zebrafish.

@article{Li2012TheAG,
  title={The Amotl2 gene inhibits Wnt/β-catenin signaling and regulates embryonic development in zebrafish.},
  author={Zhiqiang Li and Yeqi Wang and Min Zhang and Pengfei Xu and Huizhe Huang and Di Wu and Anming Meng},
  journal={The Journal of biological chemistry},
  year={2012},
  volume={287 16},
  pages={13005-15}
}
The Motin family proteins can regulate cell polarity, cell mobility, and proliferation during embryonic development by controlling distinct signaling pathways. In this study, we demonstrate that amotl2 knockdown in zebrafish wild-type embryos results in embryonic dorsalization, and this effect can be antagonized by co-knockdown of the dorsal inducer β-catenin2. Overexpression of amotl2 in masterblind (mbl) homozygous embryos, in which canonical Wnt signaling is up-regulated due to an axin1… CONTINUE READING