The Amino Terminus of the Yeast F 1-ATPase { j-Subunit Precursor Functions as a Mitochondrial Import Signal


The ATP2 gene of Saccharomyces cerevisiae codes for the cytoplasmically synthesized ,8-subunit protein of the mitochondrial F,-ATPase. To define the amino acid sequence determinants necessary for the in vivo targeting and import of this protein into mitochondria, we have constructed gene fusions between the ATP2 gene and either the Escherichia coli lacZ… (More)

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