The Ames Salmonella/microsome mutagenicity assay.

@article{Mortelmans2000TheAS,
  title={The Ames Salmonella/microsome mutagenicity assay.},
  author={K. Mortelmans and E. Zeiger},
  journal={Mutation research},
  year={2000},
  volume={455 1-2},
  pages={
          29-60
        }
}
The Ames Salmonella/microsome mutagenicity assay (Salmonella test; Ames test) is a short-term bacterial reverse mutation assay specifically designed to detect a wide range of chemical substances that can produce genetic damage that leads to gene mutations. The test employs several histidine dependent Salmonella strains each carrying different mutations in various genes in the histidine operon. These mutations act as hot spots for mutagens that cause DNA damage via different mechanisms. When the… Expand
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Isolation of plasmid pKM101 in the Stocker laboratory.
Microbial Mutagenicity Assay: Ames Test.
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