The Alzheimer amyloid precursor protein. Identification of a stable intermediate in the biosynthetic/degradative pathway.

Abstract

The amyloid forming beta-peptide of Alzheimer's disease is synthesized as part of a larger integral membrane precursor protein (beta APP) of which three alternatively spliced versions of 695, 751, and 770 amino acids have been described. A fourth beta APP form of 563 amino acids does not contain the beta-peptide region. Recent experiments using transient… (More)

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Cite this paper

@article{Oltersdorf1990TheAA, title={The Alzheimer amyloid precursor protein. Identification of a stable intermediate in the biosynthetic/degradative pathway.}, author={Tillman Oltersdorf and P. J. Ward and Thomas Henriksson and Eric C. Beattie and R A Neve and Ivan M. Lieberburg and Lawrence C. Fritz}, journal={The Journal of biological chemistry}, year={1990}, volume={265 8}, pages={4492-7} }