• DOI:10.1038/ng0195-21
Corpus ID: 20016461

The Alzheimer's Aβ peptide induces neurodegeneration and apoptotic cell death in transgenic mice

@article{Laferla1995TheAA,
  title={The Alzheimer's Aβ peptide induces neurodegeneration and apoptotic cell death in transgenic mice},
  author={F. Laferla and B. Tinkle and Charles J. Bieberich and C. Haudenschild and G. Jay},
  journal={Nature Genetics},
  year={1995},
  volume={9},
  pages={21-30}
}

• F. Laferla, B. Tinkle, +2 authors G. Jay
• Published 1995
• Biology, Medicine
• Nature Genetics

To test whether the hypothesis that the Alzheimer's Aβ peptide is neurotoxic, we introduced a transgene into mice to direct expression of this peptide to neurons. We show that the transgene is expressed in brain regions which are severely affected in Alzheimer's disease resulting in extensive neuronal degeneration. Morphological and biochemical evidence indicates that the eventual death of these cells occurs by apoptosis. Coincident with the cell degeneration and cell death is the presence of a… Expand

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