The Alzheimer's Aβ peptide induces neurodegeneration and apoptotic cell death in transgenic mice

@article{Laferla1995TheAA,
  title={The Alzheimer's Aβ peptide induces neurodegeneration and apoptotic cell death in transgenic mice},
  author={F. Laferla and B. Tinkle and Charles J. Bieberich and C. Haudenschild and G. Jay},
  journal={Nature Genetics},
  year={1995},
  volume={9},
  pages={21-30}
}
To test whether the hypothesis that the Alzheimer's Aβ peptide is neurotoxic, we introduced a transgene into mice to direct expression of this peptide to neurons. We show that the transgene is expressed in brain regions which are severely affected in Alzheimer's disease resulting in extensive neuronal degeneration. Morphological and biochemical evidence indicates that the eventual death of these cells occurs by apoptosis. Coincident with the cell degeneration and cell death is the presence of a… Expand
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References

SHOWING 1-10 OF 67 REFERENCES
Apoptosis is induced by beta-amyloid in cultured central nervous system neurons.
  • 1,034
  • PDF
Astroglia in Alzheimer's disease
  • 122
Deposition of beta/A4 immunoreactivity and neuronal pathology in transgenic mice expressing the carboxyl-terminal fragment of the Alzheimer amyloid precursor in the brain.
  • 151
  • PDF
Expression of the human beta-amyloid precursor protein gene from a yeast artificial chromosome in transgenic mice.
  • B. Pearson, T. Choi
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences of the United States of America
  • 1993
  • 81
  • PDF
...
1
2
3
4
5
...