The Alternative Route to Heme in the Methanogenic Archaeon Methanosarcina barkeri

@inproceedings{Khner2014TheAR,
  title={The Alternative Route to Heme in the Methanogenic Archaeon Methanosarcina barkeri},
  author={Melanie K{\"u}hner and Kristin Haufschildt and Alexander Neumann and Sonja Storbeck and Judith Streif and Gunhild Layer},
  booktitle={Archaea},
  year={2014}
}
In living organisms heme is formed from the common precursor uroporphyrinogen III by either one of two substantially different pathways. In contrast to eukaryotes and most bacteria which employ the so-called "classical" heme biosynthesis pathway, the archaea use an alternative route. In this pathway, heme is formed from uroporphyrinogen III via the intermediates precorrin-2, sirohydrochlorin, siroheme, 12,18-didecarboxysiroheme, and iron-coproporphyrin III. In this study the heme biosynthesis… CONTINUE READING
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