The Altered Reconfiguration Pattern of Brain Modular Architecture Regulates Cognitive Function in Cerebral Small Vessel Disease

  title={The Altered Reconfiguration Pattern of Brain Modular Architecture Regulates Cognitive Function in Cerebral Small Vessel Disease},
  author={Renyuan Liu and Haifeng Chen and Ruomeng Qin and Yucheng Gu and Xin Chen and Junhui Zou and Yongcheng Jiang and Weikai Li and Feng Bai and Bing Zhang and Xiaoying Wang and Yun Xu},
  journal={Frontiers in Neurology},
Background: Cerebral small vessel disease (SVD) is a common cause of cognitive dysfunction. However, little is known whether the altered reconfiguration pattern of brain modular architecture regulates cognitive dysfunction in SVD. Methods: We recruited 25 cases of SVD without cognitive impairment (SVD-NCI) and 24 cases of SVD with mild cognitive impairment (SVD-MCI). According to the Framingham Stroke Risk Profile, healthy controls (HC) were divided into 17 subjects (HC-low risk) and 19… 

Figures and Tables from this paper

Medial Temporal Atrophy Contributes to Cognitive Impairment in Cerebral Small Vessel Disease
AccuBrain™ technology showed that MTA was related to cognition impairment in CSVD patients, which might become a potential imaging marker for CSVD-CI.
Modified cerebral small vessel disease score is associated with vascular cognitive impairment after lacunar stroke
The results suggest that both the total and modified SVD scores show a negative association with cognitive function, but themodified SVD score may be better at identifying patients at high VCI risk.
Functional Disorganization of Small-World Brain Networks in Patients With Ischemic Leukoaraiosis
Cognitive impairment is a key clinical feature of ischemic leukoaraiosis (ILA); however, the underlying neurobiological mechanism is still unclear. ILA has been associated with widespread gray and
Functional connectivity changes in cerebral small vessel disease - a systematic review of the resting-state MRI literature
It is suggested that the salience network might play a hitherto underappreciated role in this model of cognitive impairment in CSVD, and the low quality of evidence and the lack of preregistered multi-centre studies remain challenges to be overcome in the future.
Nodal Global Efficiency in Front-Parietal Lobe Mediated Periventricular White Matter Hyperintensity (PWMH)-Related Cognitive Impairment
It is found that WMH-CIND subjects displayed decreased global efficiency at the levels of the whole brain, specific subnetworks [fronto-parietal network (FPN) and cingulo-opercular network (CON)] and certain nodes located in the FPN and CON, as well as decreased local efficiency in subnets.
Disrupted topological organization of resting‐state functional brain networks in cerebral small vessel disease
The results suggest that CSVD patients with and without CMBs had segregated disruptions in the topological organization of the intrinsic functional brain network, advancing the current understanding of the pathophysiological mechanisms underlying CSVD.
Total Small Vessel Disease Burden Predicts Functional Outcome in Patients With Acute Ischemic Stroke
MRI-based assessment of total SVD burden is highly valuable in clinical management of stroke victims and could help guide the allocation of resources to improve outcome and is superior to individual SVD feature in prediction of functional outcome.
Regional cerebral perfusion in patients with amnestic mild cognitive impairment: effect of cerebral small vessel disease
CSVD could interact with pathological changes related to AD, exacerbating hypoperfusion in BAs 21, 23, 28, 36, 38 while compensating for cerebral blood perfusion disorder in BA 7-left in MCI patients.
Altered Granger Causal Connectivity of Resting-State Neural Networks in Patients With Leukoaraiosis-Associated Cognitive Impairment—A Cross-Sectional Study
The components of resting-state networks kept changing as the disease progressed, and the direction and strength of connections between these networks changed and remodeled differently, suggesting that the human brain compensates for specific functional changes at different stages.
Not Only in Sensorimotor Network: Local and Distant Cerebral Inherent Activity of Chronic Ankle Instability—A Resting-State fMRI Study
The CAI patients exhibited enhanced and more coherent regional inherent neuronal activity within the sensorimotor network while lower regional inherent activity in pain/emotion modulation related region, which may provide insights into the pathophysiological alteration in CNS amongCAI patients.


Graph theoretical analysis of functional networks and its relationship to cognitive decline in patients with carotid stenosis
  • Ting-Yu ChangKuo-Lun Huang Ho-Ling Liu
  • Psychology
    Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism
  • 2016
Specific indices (global efficiency, characteristic path length, and modularity) were highly correlated with neuropsychological performance in patients with carotid stenosis and analysis of brain connectivity may help to elucidate the relationship between hemodynamic impairment and cognitive decline.
Disruption of rich club organisation in cerebral small vessel disease
The rich club organisation is investigated and reduced connectivity was found in SVD, which was preferentially located in the connectivity between the rich club nodes rather than in the feeder and peripheral connections, a finding confirmed in both datasets.
Structural network efficiency predicts conversion to dementia
Results support a role of network disruption playing a pivotal role in the genesis of dementia in SVD, and suggest network analysis of the connectivity of white matter has potential as a predictive marker in the disease.
Apolipoprotein E ε4 modulates functional brain connectome in Alzheimer's disease
The findings suggest that the APOE genotype modulates large‐scale brain networks in AD and shed new light on the gene‐connectome interaction in this disease.
Pathogenesis of white matter changes in cerebral small vessel diseases: beyond vessel-intrinsic mechanisms.
A new and critical look at the pathogenesis of SVD-associated white matter (WM) changes is provided, building on two recent seminal studies that have uncovered an anatomical and functional relationship between oligodendrocyte progenitor cells and blood vessels.
Loss of white matter integrity is associated with gait disorders in cerebral small vessel disease.
It is demonstrated that, in elderly subjects with small vessel disease, widespread disruption of white matter integrity, predominantly in the normal-appearing white matter, is involved in gait disturbances.
Brain network functional connectivity and cognitive performance in major depressive disorder.
Resting state and task‐induced deactivation: A methodological comparison in patients with schizophrenia and healthy controls
Results indicated that TID analyses, ICA, and seed‐based correlation all consistently identified the midline (anterior and posterior cingulate gyrus) and lateral parietal cortex as core regions of the DMN, as well as more variable involvement of temporal lobe structures.