The Alpha-2A-Adrenoceptor Agonist, Guanfacine, Increases Regional Cerebral Blood Flow in Dorsolateral Prefrontal Cortex of Monkeys Performing a Spatial Working Memory Task

@article{Avery2000TheAA,
  title={The Alpha-2A-Adrenoceptor Agonist, Guanfacine, Increases Regional Cerebral Blood Flow in Dorsolateral Prefrontal Cortex of Monkeys Performing a Spatial Working Memory Task},
  author={Robert A. Avery and Jenna S. Franowicz and Colin Studholme and Christopher H. van Dyck and Amy F. T. Arnsten},
  journal={Neuropsychopharmacology},
  year={2000},
  volume={23},
  pages={240-249}
}
Research indicates that norepinephrine enhances the working memory functions of the prefrontal cortex (PFC) through actions at post-synaptic, alpha-2A adrenoceptors. The current study examined the effects of the alpha-2A adrenoreceptor agonist, guanfacine (0.7 mg/kg, i.m.), compared to saline on SPECT measures of regional cerebral blood flow (rCBF) in monkeys performing a spatial working memory task. Animals were infused with the SPECT blood flow tracer, Tcm-99m ECD, through an indwelling… CONTINUE READING
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Guanfacine for treatment of Attention-Deficit-Hyperactivity Disorder in boys

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