The Alkali Metal Ions: Their Role for Life

  title={The Alkali Metal Ions: Their Role for Life},
  author={Astrid Sigel and Helmut Sigel and Roland K. O. Sigel},
  journal={Metal ions in life sciences},
MILS-16 provides an up-to-date review of the impact of alkali metal ions on life. Their bioinorganic chemistry and analytical determination, the solid state structures of bio-ligand complexes and the properties of alkali metal ions in solution in the context of all kinds of biologically relevant ligands are covered, this includes proteins (enzymes) and nucleic acids (G-quadruplexes). Minerals containing sodium (Na + ) and potassium (K + ) are abundant in the Earth's crust, making Na + and K… 

Alkali Metal Chelation by 3–Hydroxy–4–Pyridinone

Chelations of neutral and one–electron positive ionic alkali metals including Lithium (Li/Li+), Sodium (Na/Na+) and Potassium (K/K+) by 3–Hydroxy–4–Pyridinone (HPO) have been investigated by the in

The bio-relevant metals of the periodic table of the elements

Abstract The bio-relevant metals (and derived compounds) of the Periodic Table of the Elements (PTE) are in the focus. The bulk elements sodium (Na), potassium (K), magnesium (Mg), and calcium (Ca)

The interaction of NOTA as a bifunctional chelator with competitive alkali metal ions: a DFT study

1,4,7-Triazacyclononane-1,4,7-triacetic acid (NOTA) is a key chelator for radiolabelling pharmaceuticals. The ability of alkali metals in the human body to complex with NOTA and compete with

Highly Selective Detection of K+ Based on a Dimerized G-Quadruplex DNAzyme.

A K+ specific biosensor is constructed on the basis of a dimerized G-quadruplex (GQ) DNA, which is promoted by K+, and the enzymatic activity of the resulting DNAzyme depends on the concentration of the K+.

Alkali Cation Effects on Redox-Active Formazanate Ligands in Iron Chemistry.

The effects of interactions with alkali-metal cations within a series of reduced iron complexes bearing a redox-active formazanate ligand are described, in terms of structures, magnetism, spectroscopy, and reaction rates.

Distinct differences in metal ion specificity of RNA and DNA G-quadruplexes

The results show that the RNA quadruplexes are more stable than their DNA counterparts under the same buffer conditions, and the difference in response between NRAS and TERRA, as well as to the corresponding DNA sequences with respect to different metal ions, could potentially be exploited for selective targeting purposes.

Evolution of cation binding in the active sites of P-loop nucleoside triphosphatases

Comparative structure analysis of P-loop NTPases of various classes with molecular dynamics simulations of Mg-ATP complexes in water and in the presence of potassium, sodium, or ammonium ions found the conserved P- loop motif keeps the triphosphate chains of enzyme-bound NTPs in an extended, catalytically prone conformation, similar to that attained by ATP in water.

The phenoxyl group-modulated interplay of cation-π and σ-type interactions in the alkali metal series.

It is argued that the combined effect of cation dimensions and hydroxyl substitution in catechol-Na+ complexes makes σ-type configurations remarkably more stable and easily accessible than cation-π ones, which may offer a useful reference for tuning accurate force fields.

Evolution of cation binding in the active sites of P-loop nucleoside triphosphatases in relation to the basic catalytic mechanism

Comparative structure analysis with molecular dynamics simulations of Mg-ATP and MG-GTP complexes in water and in the presence of potassium, sodium, or ammonium ions revealed an almost eclipsed, catalytically productive conformation of the triphosphate chain, which could represent the basic mechanism of hydrolysis by P-loop NTPases.



Principles of nucleic acid structure

Ionophores and Their Structures

Provides a comprehensive survey of the three-dimensional structure of ionophores. Supplements the stereoscopic picture of the molecule with a list of orthogonal coordinates for constituent atoms.

Comprehensive Supramolecular Chemistry

The comprehensive supramolecular chemistry is universally compatible with any devices to read, and will help you to enjoy a good book with a cup of coffee in the afternoon instead of dealing with some malicious virus inside their desktop computer.

The Nature Of The Chemical Bond

The the nature of the chemical bond is universally compatible with any devices to read, and is available in the authors' digital library an online access to it is set as public so you can get it instantly.

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