The Aldehyde Oxidase Gene Cluster in Mice and Rats

  title={The Aldehyde Oxidase Gene Cluster in Mice and Rats},
  author={Mami Kurosaki and Mineko Terao and Maria Monica Barzago and Antonio Bastone and Davide Bernardinello and Mario Salmona and Enrico Garattini},
  journal={Journal of Biological Chemistry},
  pages={50482 - 50498}
Mammalian molybdo-flavoenzymes are oxidases requiring FAD and molybdopterin (molybdenum cofactor) for their catalytic activity. This family of proteins was thought to consist of four members, xanthine oxidoreductase, aldehyde oxidase 1 (AOX1), and the aldehyde oxidase homologues 1 and 2 (AOH1 and AOH2, respectively). Whereas the first two enzymes are present in humans and various other mammalian species, the last two proteins have been described only in mice. Here, we report on the… 

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