The Ala-9Val polymorphism in the mitochondrial targeting sequence (MTS) of the manganese superoxide dismutase gene is not associated with juvenile-onset asthma.

Abstract

BACKGROUND We aimed to investigate the possible association between Mn-SOD polymorphism in the mitochondrial targeting sequence and asthma. METHODS Alanine or valine polymorphism in the signal peptide of Mn-SOD gene was evaluated using a primer pair to amplify a 107-bp fragment followed by digestion with NgoM IV. RESULTS No significant difference in genotype frequencies was found between patients and controls. CONCLUSION These results suggest no major modifying role for the Mn-SOD gene polymorphism in patients with asthma.

Cite this paper

@article{Gurel2004TheAP, title={The Ala-9Val polymorphism in the mitochondrial targeting sequence (MTS) of the manganese superoxide dismutase gene is not associated with juvenile-onset asthma.}, author={Ahmet Gurel and Nazan Tomaç and Hacı Ramazan Yilmaz and Ibrahim Tekedereli and Omer Akyol and Ferah Armutçu and Huseyin Yuce and Haluk M. Akin and Nurten Ozçelik and Halit Elyas}, journal={Clinical biochemistry}, year={2004}, volume={37 12}, pages={1117-20} }