The Ageing Brain: Age-dependent changes in the electroencephalogram during propofol and sevoflurane general anaesthesia.

@article{Purdon2015TheAB,
  title={The Ageing Brain: Age-dependent changes in the electroencephalogram during propofol and sevoflurane general anaesthesia.},
  author={Patrick L. Purdon and Kara Jean Pavone and Oluwaseun Akeju and Ayanay Camille Ferguson Smith and Aaron L. Sampson and Jennifer H Lee and Dawang Zhou and Ken Solt and Emery N. Brown},
  journal={British journal of anaesthesia},
  year={2015},
  volume={115 Suppl 1},
  pages={i46-i57}
}
BACKGROUND Anaesthetic drugs act at sites within the brain that undergo profound changes during typical ageing. We postulated that anaesthesia-induced brain dynamics observed in the EEG change with age. METHODS We analysed the EEG in 155 patients aged 18-90 yr who received propofol (n=60) or sevoflurane (n=95) as the primary anaesthetic. The EEG spectrum and coherence were estimated throughout a 2 min period of stable anaesthetic maintenance. Age-related effects were characterized by… CONTINUE READING
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