The Administration of rt-PA (Activase®) for the Treatment of Empyema in an Adult Patient

  title={The Administration of rt-PA (Activase®) for the Treatment of Empyema in an Adult Patient},
  author={Christopher R. Emerson and Christine M. Bercume and Marilena S. Antonopoulos and Nino Marzella},
  journal={Journal of Pharmacy Practice},
  pages={117 - 123}
The administration of various fibrinolytic agents for the treatment of empyema has been reported in past studies. Most of the current literature has shown favorable outcomes in terms of increased tube drainage, improved chest radiography, and reduction in surgical intervention. However, a randomized controlled trial that compared streptokinase to placebo showed no significant reduction in mortality. To date, there have been no randomized controlled trials evaluating the safety, efficacy, and… Expand
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