The Adipophilin C Terminus Is a Self-folding Membrane-binding Domain That Is Important for Milk Lipid Secretion*

@article{Chong2011TheAC,
  title={The Adipophilin C Terminus Is a Self-folding Membrane-binding Domain That Is Important for Milk Lipid Secretion*},
  author={Brandi M. Chong and Tanya D. Russell and Jerome B. Schaack and David J. Orlicky and Philip Reigan and Mark S. Ladinsky and James L. McManaman},
  journal={The Journal of Biological Chemistry},
  year={2011},
  volume={286},
  pages={23254 - 23265}
}
Cytoplasmic lipid droplets (CLD) in mammary epithelial cells undergo secretion by a unique membrane envelopment process to produce milk lipids. Adipophilin (ADPH/Plin2), a member of the perilipin/PAT family of lipid droplet-associated proteins, is hypothesized to mediate CLD secretion through interactions with apical plasma membrane elements. We found that the secretion of CLD coated by truncated ADPH lacking the C-terminal region encoding a putative four-helix bundle structure was impaired… Expand
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