The Adenylate cyclase-cyclic AMP system in islets of langerhans and its role in the control of insulin release

@article{Sharp1979TheAC,
  title={The Adenylate cyclase-cyclic AMP system in islets of langerhans and its role in the control of insulin release},
  author={Geoffrey W. G. Sharp},
  journal={Diabetologia},
  year={1979},
  volume={16},
  pages={287-296}
}
The mechanisms by which glucose and other stimulators control the rate of insulin release from the /3-cells of islets of Langerhans is still far from understood. In general terms, it is assumed that a receptor for a glucose metabolite is the initiator of interactions leading to increased insulin release. These interactions may involve cyclic AMP, Ca ++ , cytosol components, microfilaments and microtubules, the insulin containing granule membranes and the Ncell plasma membrane, and lead to… CONTINUE READING

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Effects of pregnancy on insulin and glucagon secretion by perifused rat pancreatic islets

  • R. K. Kalkhoff, Kim, H.-J.
  • Endocrinology 102, 623-631
  • 1978
1 Excerpt

Stimulation of specific protein phosphorylation in intact rat islets of Langerhans by both 3-isobutyl-l-methylxanthine and D-glucose

  • Lipson. L.G., C. Vachon, C. A. Forristall, G.W.G. Sharp
  • Clin. Res. 26, 530A
  • 1978
1 Excerpt

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