The Adenovirus Type 5 E1B-55K Oncoprotein Actively Shuttles in Virus-Infected Cells, Whereas Transport of E4orf6 Is Mediated by a CRM1-Independent Mechanism

@article{Dosch2001TheAT,
  title={The Adenovirus Type 5 E1B-55K Oncoprotein Actively Shuttles in Virus-Infected Cells, Whereas Transport of E4orf6 Is Mediated by a CRM1-Independent Mechanism},
  author={T. Dosch and F. Horn and G. Schneider and F. Kr{\"a}tzer and T. Dobner and J. Hauber and R. Stauber},
  journal={Journal of Virology},
  year={2001},
  volume={75},
  pages={5677 - 5683}
}
  • T. Dosch, F. Horn, +4 authors R. Stauber
  • Published 2001
  • Biology, Medicine
  • Journal of Virology
  • ABSTRACT The E1B-55K and E4orf6 proteins of adenovirus type 5 are involved in viral mRNA export. Here we demonstrate that adenovirus infection does not inhibit the function of the E1B-55K nuclear export signal and that E1B-55K also shuttles in infected cells. Even during virus infection, E1B-55K was exported by the leptomycin B-sensitive CRM1 pathway, whereas E4orf6 transport appeared to be mediated by an alternative mechanism. Our results strengthen the potential role of E1B-55K as the… CONTINUE READING
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