The Adenine Nucleotide Translocator: Regulation And Function During Myocardial Development And Hypertrophy

@article{Portman2002TheAN,
  title={The Adenine Nucleotide Translocator: Regulation And Function During Myocardial Development And Hypertrophy},
  author={Michael A. Portman},
  journal={Clinical and Experimental Pharmacology and Physiology},
  year={2002},
  volume={29}
}
  • M. Portman
  • Published 1 April 2002
  • Biology
  • Clinical and Experimental Pharmacology and Physiology
1. The present review focuses on the adenine nucleotide translocator (ANT), which facilitates exchange of cytosolic ADP for mitochondrial ATP. This protein serves a central role in regulating cellular oxidative capacity. 
View on Wiley
faculty.washington.edu
21 Citations
Highly Influential Citations
1
Background Citations
5
Methods Citations
1

21 Citations

Citation Type

Citation Type

Mitochondrial Bioenergetics in the Heart
Mitochondrial disorders in chagasic cardiomyopathy.
  • N. Garg
  • Biology, Medicine
    Frontiers in bioscience : a journal and virtual library
  • 2005
TLDR
This article highlights current information about the potential etiology and the pathophysiological significance of mitochondrial dysfunction in chagasic cardiomyopathy, and provides a brief background of mitochondrial biogenesis and bioenergetic pathways in cardiac growth and development.
Thyroid hormone and myocardial mitochondrial biogenesis.
Adenine nucleotide translocase 1 deficiency results in dilated cardiomyopathy with defects in myocardial mechanics, histopathological alterations, and activation of apoptosis.
Bioenergetics Interplay Between Cardiac Mitochondria and Other Subcellular Compartments
TLDR
Direct functional interplay exists in cardiomyocytes between mitochondria and other subcellular compartments that makes it possible direct energy and signal channeling between organelles.
Thyroid Hormone and Myocardial Mitochondria
The ability of thyroid hormone to regulate energy utilization was first recognized more than 100 years ago and is still a contemporary topic in thyroid research. To date, we still do not understand…
Nuclear-mitochondrial cross-talk in cardiomyocyte T3 signaling: a time-course analysis.
Myocardial overexpression of adenine nucleotide translocase 1 ameliorates diabetic cardiomyopathy in mice
TLDR
Cardiomyocyte‐restricted overexpression of ANT1 prevents the development of diabetic cardiomyopathy; therefore, accelerated ADP/ATP exchange could be a new promising target to treat diabetic carduomyopathy.
Bioenergetic remodeling of heart mitochondria by thyroid hormone
TLDR
Findings indicate parallel increases in myocardial mitochondrial bioenergetic capacity, oxygen consumption and markers of mitochondrial biogenesis with 15-day T4; these changes were not present with 10- day T4 even with significant cardiac hypertrophy.
Cardiac Metabolic Changes in Altered Thyroid States
TLDR
Clinical studies have shown that thyroid hormone supplementation in altered states improves cardiac function, and studies in animal models emulating clinical scenarios with disrupted thyroid homeostasis demonstrate that thyroid supplementation promotes flux through pyruvate dehydrogenase (PDH) in the heart along with preservation of high-energy phosphate reserves and contractile function.
...
1
2
3
...

References

SHOWING 1-10 OF 35 REFERENCES
On the origin of the limited control of mitochondrial respiration by the adenine nucleotide translocator.
Thyroid Hormone Coordinates Respiratory Control Maturation and Adenine Nucleotide Translocator Expression in Heart In Vivo
TLDR
Data imply that the maturational shift away from ADP-mediated respiratory control is regulated by thyroid hormone in vivo, and specific thyroid-modulated increases in ANT mRNA and protein imply that this regulation occurs in part at a pretranslational level.
Expression of adenine nucleotide translocator parallels maturation of respiratory control in heart in vivo.
TLDR
Data indicate that respiratory control pattern in the newborn is consistent with a kinetic type regulation through ANT, maturational decreases in control in sheep heart are paralleled by specific increases in ANT content, and regulation of these changes in ANt may be related to increases in steady-state transcript levels for its gene.
Signaling and expression for mitochondrial membrane proteins during left ventricular remodeling and contractile failure after myocardial infarction.
Differential expression of adenine nucleotide translocator isoforms in mammalian tissues and during muscle cell differentiation.
Regulation of adenine nucleotide translocase and glycerol 3-phosphate dehydrogenase expression by thyroid hormones in different rat tissues.
TLDR
It is concluded that the T3-mediated transcriptional induction leading to increased activity of ANT2 and mGPDH contributes considerably to the increase in mitochondrial oxygen consumption in rat tissues.
Myocardial Energetics In Cardiac Hypertrophy
1. This review is presented with the intent of illustrating the representative studies of functional and myocardial energetic consequences of hearts with postinfarction left ventricular (LV)…
Expression of the ADP/ATP carrier and expansion of the mitochondrial (ATP + ADP) pool contribute to postnatal maturation of the rat heart.
TLDR
The data strongly indicate that the increase in the AAC activity is an essential step in the postnatal maturation of rat heart mitochondria.
Control of oxidative phosphorylation in rat heart mitochondria. The role of the adenine nucleotide carrier.
The Signal Transduction Function for Oxidative Phosphorylation Is at Least Second Order in ADP*
To maintain ATP constant in the cell, mitochondria must sense cellular ATP utilization and transduce this demand to F0-F1-ATPase. In spite of a considerable research effort over the past three…
...
1
2
3
4
...