The Addition of Low-Dose Total Body Irradiation to Fludarabine and Melphalan Conditioning in Haplocord Transplantation for High-Risk Hematological Malignancies.

@article{Choe2017TheAO,
  title={The Addition of Low-Dose Total Body Irradiation to Fludarabine and Melphalan Conditioning in Haplocord Transplantation for High-Risk Hematological Malignancies.},
  author={Hannah K Choe and Usama S Gergis and Sebastian A Mayer and Himanshu Nagar and Adrienne Alise Phillips and Tsiporah B. Shore and Michael J. Smith and Koen van Besien},
  journal={Transplantation},
  year={2017},
  volume={101 1},
  pages={e34-e38}
}
BACKGROUND Preliminary evidence indicates that the addition of low-dose total body irradiation (TBI) (2-4 Gy) to reduced intensity conditioning may reduce the rate of relapse in allogeneic stem cell transplants. In very high-risk patients receiving combination haploidentical single-unit cord blood transplants, we have added 4 Gy TBI to the widely used fludarabine, melphalan conditioning regimen, in hopes of reducing relapse and decreasing graft rejection. METHODS We retrospectively reviewed… CONTINUE READING