The Addition of Epinephrine to Tetracaine Injected Intrathecally Sustains an Increase in Glutamate Concentrations in the Cerebrospinal Fluid and Worsens Neuronal Injury

@article{Oka2001TheAO,
  title={The Addition of Epinephrine to Tetracaine Injected Intrathecally Sustains an Increase in Glutamate Concentrations in the Cerebrospinal Fluid and Worsens Neuronal Injury},
  author={S. Oka and M. Matsumoto and K. Ohtake and T. Kiyoshima and K. Nakakimura and T. Sakabe},
  journal={Anesthesia & Analgesia},
  year={2001},
  volume={93},
  pages={1050–1057}
}
  • S. Oka, M. Matsumoto, +3 authors T. Sakabe
  • Published 2001
  • Medicine
  • Anesthesia & Analgesia
  • We have reported that large concentrations of intrathecal tetracaine increase glutamate concentrations in the cerebrospinal fluid (CSF) and cause neuronal injury in the spinal cord. In this study, we investigated whether the addition of epinephrine to tetracaine modulates these events. New Zealand white rabbits were assigned into five groups (six rabbits in each group) and intrathecally received 0.3 mL of epinephrine 0.1 mg/mL in NaCl solution (control), 1% tetracaine dissolved in saline (1%T… CONTINUE READING
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