The AddAB helicase–nuclease catalyses rapid and processive DNA unwinding using a single Superfamily 1A motor domain

@inproceedings{Yeeles2011TheAH,
  title={The AddAB helicase–nuclease catalyses rapid and processive DNA unwinding using a single Superfamily 1A motor domain},
  author={Joseph T. P. Yeeles and Emma Jane Gwynn and Martin R Webb and Mark S Dillingham},
  booktitle={Nucleic acids research},
  year={2011}
}
The oligomeric state of Superfamily I DNA helicases is the subject of considerable and ongoing debate. While models based on crystal structures imply that a single helicase core domain is sufficient for DNA unwinding activity, biochemical data from several related enzymes suggest that a higher order oligomeric species is required. In this work we characterize the helicase activity of the AddAB helicase-nuclease, which is involved in the repair of double-stranded DNA breaks in Bacillus subtilis… CONTINUE READING

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