The Activation-induced Deaminase Functions in a Postcleavage Step of the Somatic Hypermutation Process

@article{Papavasiliou2002TheAD,
  title={The Activation-induced Deaminase Functions in a Postcleavage Step of the Somatic Hypermutation Process},
  author={F Nina Papavasiliou and David G Schatz},
  journal={The Journal of Experimental Medicine},
  year={2002},
  volume={195},
  pages={1193 - 1198}
}
Activation of B cells by antigen fuels two distinct molecular modifications of immunoglobulin (Ig) genes. Class-switch recombination (CSR) replaces the Ig(mu) heavy chain constant region with a downstream constant region gene, thereby altering the effector function of the resulting antibodies. Somatic hypermutation (SHM) introduces point mutations into the variable regions of Ig genes, thereby changing the affinity of antibody for antigen. Mechanistic overlap between the two reactions has been… CONTINUE READING

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Molecular processes that regulate class switching.

Current topics in microbiology and immunology • 2000

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