The Actions of Synaptically Released Zinc at Hippocampal Mossy Fiber Synapses

@article{Vogt2000TheAO,
  title={The Actions of Synaptically Released Zinc at Hippocampal Mossy Fiber Synapses},
  author={Kaspar Vogt and Jack Mellor and Gang Tong and Roger A Nicoll},
  journal={Neuron},
  year={2000},
  volume={26},
  pages={187-196}
}
Zn2+ is present at high concentrations in the synaptic vesicles of hippocampal mossy fibers. We have used Zn2+ chelators and the mocha mutant mouse to address the physiological role of Zn2+ in this pathway. Zn2+ is not involved in the unique presynaptic plasticities observed at mossy fiber synapses but is coreleased with glutamate from these synapses, both spontaneously and with electrical stimulation, where it exerts a strong modulatory effect on the NMDA receptors. Zn2+ tonically occupies the… CONTINUE READING
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