The Action of Two Sulfhydryl Compounds on Normal Human Red Cells. Relationship to Red Cells of Paroxysmal Nocturnal Hemoglobinuria.

@article{Sirchia1965TheAO,
  title={The Action of Two Sulfhydryl Compounds on Normal Human Red Cells. Relationship to Red Cells of Paroxysmal Nocturnal Hemoglobinuria.},
  author={Girolamo Sirchia and Soldano Ferrone and F. Mercuriali},
  journal={Blood},
  year={1965},
  volume={25},
  pages={502-10}
}
characteristic lesion of the erythrocytes in the laboratory. Attempts along this line were made by Rodbard1 who, assuming that the erythrocytic defect was localized in the lipid fraction of the stroma, succeeded on a few occasions in obtaining lysis of normal red cells in acidified serum-which occurs also under the same conditions to PNH red cells2-by means of repeated washing with dilute alcoholic solutions. However, the results were not constant and reproducible. By contrast, the results… CONTINUE READING
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