The Actin-Binding Protein α-Adducin Is Required for Maintaining Axon Diameter.

@article{Leite2016TheAP,
  title={The Actin-Binding Protein α-Adducin Is Required for Maintaining Axon Diameter.},
  author={S{\'e}rgio Carvalho Leite and Paula C{\'i}ntia Machado Sampaio and Vera Filipe Sousa and Joana Nogueira-Rodrigues and Rita Pinto-Costa and Luanne Laurel Peters and Pedro Brites and Monica Sousa},
  journal={Cell reports},
  year={2016},
  volume={15 3},
  pages={490-498}
}
The actin-binding protein adducin was recently identified as a component of the neuronal subcortical cytoskeleton. Here, we analyzed mice lacking adducin to uncover the function of this protein in actin rings. α-adducin knockout mice presented progressive axon enlargement in the spinal cord and optic and sciatic nerves, followed by axon degeneration and loss. Using stimulated emission depletion super-resolution microscopy, we show that a periodic subcortical actin cytoskeleton is assembled in… CONTINUE READING
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