The Acetylcholinesterase Defect in Paroxysmal Nocturnal Hemoglobinuria: Evidence That the Enzyme Is Absent From the Cell Membrane

@article{Chow1985TheAD,
  title={The Acetylcholinesterase Defect in Paroxysmal Nocturnal Hemoglobinuria: Evidence That the Enzyme Is Absent From the Cell Membrane},
  author={F L Chow and Marilyn J Telen and Wendell F. Rosse},
  journal={Blood},
  year={1985},
  volume={66 4},
  pages={940-5}
}
Paroxysmal nocturnal hemoglobinuria (PNH) is a myelodysplastic disease characterized by erythrocytes that show abnormally increased sensitivity to complement-mediated lysis. Complement-sensitive PNH erythrocyte membranes have previously been shown to lack acetylcholinesterase (AchE) activity, but the molecular basis of this deficiency has been unclear. We have used monoclonal antibodies to four different epitopes on the AchE molecule to show that abnormal PNH erythrocytes failed to bind these… CONTINUE READING

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Paroxysmale nächtliche Hämoglobinurie

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Highly Influenced

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Defi - ciency of an erythrocyte membrane protein with complement regulatory activity in paroxysmal nocturnal hemoglobinuria

MK Pangburn, RD Schreiber, HJ Muller-Eberhard
Proc NatI Acad Sci USA • 1983

Muller - Eberhard HJ : Deficiency of an erythrocyte membrane protein with complement regulatory activity in paroxysmal nocturnal hemoglobinuria

MK Pangburn, RD Schreiber
Proc NatI Acad Sci USA • 1983

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