The Acetylation of AML1-ETO Is Required for Leukemogenesis.

  title={The Acetylation of AML1-ETO Is Required for Leukemogenesis.},
  author={L. Wang and A. Gural and F. Perna and X. Sun and X. Zhao and H. Xu and M. Hatlen and G. Huang and F. Liu and Hao Xu and T. Deblasio and S. Men{\'e}ndez and Francesca Voza and R. Roeder and S. Nimer},
Abstract 1588 Transcription factors and histones are similarly modified through acetylation, phosphorylation, ubiquitination and methylation, which impact on the transcriptional regulation of gene expression and various biological processes in normal and malignant hematopoiesis. The t(8;21) associated AML1-ETO fusion protein is found in 40% of the FAB M2 subtype of acute myeloid leukemia, but how the post-translational modification of AML1-ETO affects its leukemogenicity is largely unknown… Expand