The Accomplices of NF-κB Lead to Radioresistance.

  title={The Accomplices of NF-κB Lead to Radioresistance.},
  author={Miaomiao Bai and Xiaoxing Ma and Xiaolei Li and Xiaohui Wang and Qian G. Mei and Xiang Li and Zhiqiang Wu and Weidong Han},
  journal={Current protein & peptide science},
  volume={16 4},
Ionizing radiation (IR) plays an important role in the treatment of epithelial tumors, such as lung and prostate cancer, by wounding and killing cancer cells. However, IR also activates sophisticated anti-apoptotic transcriptional factors such that cancer cells fail to repair DNA damage and obtain resistance to apoptosis under conditions of radiotherapy. Among these transcription factors, the transcription factor nuclear factor kappa B (NF-κB) is recognized as a key feature for protecting cells… CONTINUE READING
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