The AZFc region of the Y chromosome features massive palindromes and uniform recurrent deletions in infertile men

@article{KurodaKawaguchi2001TheAR,
  title={The AZFc region of the Y chromosome features massive palindromes and uniform recurrent deletions in infertile men},
  author={Tomoko Kuroda-Kawaguchi and H. Skaletsky and L. Brown and P. Minx and Holland S. Cordum and R. Waterston and R. Wilson and S. Silber and R. Oates and S. Rozen and D. Page},
  journal={Nature Genetics},
  year={2001},
  volume={29},
  pages={279-286}
}
Deletions of the AZFc (azoospermia factor c) region of the Y chromosome are the most common known cause of spermatogenic failure. We determined the complete nucleotide sequence of AZFc by identifying and distinguishing between near-identical amplicons (massive repeat units) using an iterative mapping–sequencing process. A complex of three palindromes, the largest spanning 3 Mb with 99.97% identity between its arms, encompasses the AZFc region. The palindromes are constructed from six distinct… Expand
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