266 Citations
Insights into the domain and repeat architecture of target of rapamycin.
- Biology, ChemistryJournal of structural biology
- 2010
Structure and Assembly of the PI3K-like Protein Kinases (PIKKs) Revealed by Electron Microscopy
- Biology
- 2015
The model that emerges is that PIKKs, through their extensive interacting surfaces, integrate the information provided by multiple accessory subunits and nucleic acids to regulate their kinase activity in response to diverse stimuli.
Structure of the intact ATM/Tel1 kinase
- BiologyNature communications
- 2016
The first cryo-EM structure of ATM kinase is reported, which is an intact homodimeric ATM/Tel1 from Schizosaccharomyces pombe, and shows that two monomers directly contact head-to-head through the FAT and kinase domains.
Structural analysis of DNA-PKcs: modelling of the repeat units and insights into the detailed molecular architecture.
- BiologyJournal of structural biology
- 2004
The C-terminal Residues of Saccharomyces cerevisiae Mec1 Are Required for Its Localization, Stability, and Function
- BiologyG3: Genes, Genomes, Genetics
- 2013
A role for the C-terminus in Mec1 folding and stability is supported, and a role in the proteasome in regulating Mec 1 levels is suggested.
Structure and Assembly of the PI 3 K-like Protein Kinases ( PIKKs ) Revealed by Electron Microscopy
- Biology
- 2015
The model that emerges is that PIKKs, through their extensive interacting surfaces, integrate the information provided by multiple accessory subunits and nucleic acids to regulate their kinase activity in response to diverse stimuli.
Distant N- and C-terminal Domains Are Required for Intrinsic Kinase Activity of SMG-1, a Critical Component of Nonsense-mediated mRNA Decay*
- BiologyJournal of Biological Chemistry
- 2007
Results indicated an unexpected feature of SMG-1, i.e. that distantly located N- and C-terminal sequences were essential for the intrinsic kinase activity.
Branching the Tel2 pathway for exact fit on phosphatidylinositol 3-kinase-related kinases
- BiologyCurrent Genetics
- 2018
Recent studies of yeast cells indicate that TTT is able to form different complexes, raising a possibility that several different mechanisms regulate TTT-mediated protein stability of PIKKs.
Molecular genetic characterization of Drosophila ATM conserved functional domains.
- BiologyGenome
- 2010
Molecular characterization of eight atm (tefu) alleles identified nonsense mutations predicted to truncate conserved C-terminal domains of the dATM protein, as well as two interesting missense mutations.
ATM Activation and Its Recruitment to Damaged DNA Require Binding to the C Terminus of Nbs1
- BiologyMolecular and Cellular Biology
- 2005
It is proposed that conformational changes in the MRN complex that occur upon binding to damaged DNA are transmitted through the FXF/Y-HEAT interface to activate ATM, and this interaction also retains active ATM at sites of DNA damage.
References
SHOWING 1-10 OF 32 REFERENCES
Comparison of ARM and HEAT protein repeats.
- BiologyJournal of molecular biology
- 2001
The results illustrate that ARM and HEAT-repeat proteins, while having a common phylogenetic origin, have since diverged significantly and discuss evolutionary scenarios that could account for the great diversity of repeats observed.
Protein repeats: structures, functions, and evolution.
- BiologyJournal of structural biology
- 2001
This review considers the conundrum of how multiple repeats, which show strong structural and functional interdependencies, ever evolved from a single repeat ancestor and refers to six prolific repeat types and in other less-prolific but nonetheless interesting repeats.
The Structure of the Protein Phosphatase 2A PR65/A Subunit Reveals the Conformation of Its 15 Tandemly Repeated HEAT Motifs
- Biology, ChemistryCell
- 1999
The 400 kDa subunit of the PCAF histone acetylase complex belongs to the ATM superfamily.
- Biology, ChemistryMolecular cell
- 1998
The ATM-related cofactor Tra1 is a component of the purified SAGA complex.
- BiologyMolecular cell
- 1998
The Novel ATM-Related Protein TRRAP Is an Essential Cofactor for the c-Myc and E2F Oncoproteins
- Biology, ChemistryCell
- 1998
Human SMG-1, a novel phosphatidylinositol 3-kinase-related protein kinase, associates with components of the mRNA surveillance complex and is involved in the regulation of nonsense-mediated mRNA decay.
- BiologyGenes & development
- 2001
It is concluded that h SMG-1 plays a critical role in NMD through the direct phosphorylation of hUPF1/SMG-2 in the evolutionally conserved mRNA surveillance complex.
Structure of the FKBP12-Rapamycin Complex Interacting with Binding Domain of Human FRAP
- Chemistry, BiologyScience
- 1996
The structure of the FRB domain of FRAP clarifies both rapamycin-independent and -dependent effects observed for mutants ofFRAP and its homologs in the family of proteins related to the ataxia-telangiectasia mutant gene product, and it illustrates how a small cell-permeable molecule can mediate protein dimerization.
Structure of the nuclear transport complex karyopherin-β2–Ran˙GppNHp
- BiologyNature
- 1999
The 3.0 Å structure of the karyopherin-β2–Ran˙GppNHp complex is presented where Gpp NHp is a non-hydrolysable GTP analogue and provides a structural basis for the specificity of theKaryopherIn-β family for the GTP-bound state of Ran, as well as a rationale for interactions with the regulatory proteins ranGAP, ranGEF and ranBP1.
Structure of importin-β bound to the IBB domain of importin-α
- Chemistry, BiologyNature
- 1999
The crystal structure indicates that significant conformational changes occur when importin-β binds or releases the IBB domain domain and suggests how dissociation of the importIn-α/β heterodimer may be achieved upon nuclear entry.