The ATPase cycle of the mitotic motor CENP-E.


We have previously shown that the mitotic motor centrosome protein E (CENP-E) is capable of walking for more than 250 steps on its microtubule track without dissociating. We have examined the kinetics of this molecular motor to see if its enzymology explains this remarkable degree of processivity. We find that like the highly processive transport motor… (More)
DOI: 10.1074/jbc.M109.041210


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