The ATPase and helicase activities of Prp43p are stimulated by the G-patch protein Pfa1p during yeast ribosome biogenesis.

@article{Lebaron2009TheAA,
  title={The ATPase and helicase activities of Prp43p are stimulated by the G-patch protein Pfa1p during yeast ribosome biogenesis.},
  author={Simon Lebaron and Christophe Papin and R{\'e}gine Capeyrou and Yan-Ling Chen and Carine Froment and Bernard Monsarrat and Mich{\`e}le Caizergues-Ferrer and Mikhail Grigoriev and Yves Henry},
  journal={The EMBO journal},
  year={2009},
  volume={28 24},
  pages={3808-19}
}
Prp43p is a RNA helicase required for pre-mRNA splicing and for the synthesis of large and small ribosomal subunits. The molecular functions and modes of regulation of Prp43p during ribosome biogenesis remain unknown. We demonstrate that the G-patch protein Pfa1p, a component of pre-40S pre-ribosomal particles, directly interacts with Prp43p. We also show that lack of Gno1p, another G-patch protein associated with Prp43p, specifically reduces Pfa1p accumulation, whereas it increases the levels… CONTINUE READING

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References

Publications referenced by this paper.
Showing 1-10 of 38 references

The long unwinding road of RNA helicases.

Molecular cell • 2007
View 4 Excerpts
Highly Influenced

Spliceosome disassembly catalyzed by Prp43 and its associated components Ntr1 and Ntr2.

R Tsai, R Fu, +4 authors S Cheng
Genes & development • 2005
View 6 Excerpts
Highly Influenced

Linking functionally related genes by sensitive and quantitative characterization of genetic interaction profiles.

Proceedings of the National Academy of Sciences of the United States of America • 2008
View 1 Excerpt

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