The ATP sites of AAA+ clamp loaders work together as a switch to assemble clamps on DNA.

@article{Marzahn2014TheAS,
  title={The ATP sites of AAA+ clamp loaders work together as a switch to assemble clamps on DNA.},
  author={Melissa R. Marzahn and Jaclyn N. Hayner and Jeff A. Finkelstein and Mike O'Donnell and Linda B. Bloom},
  journal={The Journal of biological chemistry},
  year={2014},
  volume={289 9},
  pages={
          5537-48
        }
}
Clamp loaders belong to a family of proteins known as ATPases associated with various cellular activities (AAA+). These proteins utilize the energy from ATP binding and hydrolysis to perform cellular functions. The clamp loader is required to load the clamp onto DNA for use by DNA polymerases to increase processivity. ATP binding and hydrolysis are coordinated by several key residues, including a conserved Lys located within the Walker A motif (or P-loop). This residue is required for each… CONTINUE READING

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