The ATP-sensitive potassium channel blocker glibenclamide prevents renal ischemia/reperfusion injury in rats.

@article{Pompermayer2005TheAP,
  title={The ATP-sensitive potassium channel blocker glibenclamide prevents renal ischemia/reperfusion injury in rats.},
  author={K{\^e}nia Pompermayer and Danielle G Souza and Giovanna Gomes Lara and K{\'a}tia Daniela da Silveira and Geovanni dantas Cassali and Anderson Assunç{\~a}o Andrade and Cl{\'a}udio A Bonjardim and K{\'a}tia T Passaglio and Jamil Assreuy and Fernando Q Cunha and Maria Aparecida Ribeiro Vieira and Mauro M Teixeira},
  journal={Kidney international},
  year={2005},
  volume={67 5},
  pages={1785-96}
}
BACKGROUND Renal ischemia/reperfusion (I/R) is a complex neutrophil-mediated syndrome. Adenosine-triphosphate (ATP)-sensitive potassium (K(ATP)) channels are involved in neutrophil migration in vivo. In the present study, we have investigated the effects of glibenclamide, a K(ATP) channel blocker, in renal I/R injury in rats. METHODS The left kidney of… CONTINUE READING